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Inwazja silnego i uporczywego bólu, niezale?nie od jego etiologii – czy to ból ostry pooperacyjny, przewlek?y ból nowotworowy, czy ból neuropatyczny – stanowi jedno z najwi?kszych wyzwa? dla wspó?czesnej medycyny. W takich przypadkach, leki opioidowe, ze wzgl?du na ich niezrównan? skuteczno?? przeciwbólow?, s? cz?sto niezb?dnym elementem